- Wendi McLendon-Covey as Beverly Goldberg
- Jeff Garlin as Murray Goldberg
- Hayley Orrantia as Erica Goldberg
- Troy Gentile as Barry Goldberg
- Sean Giambrone as Adam Goldberg
- Sam Lerner as Geoff Schwartz
- Kenny Ridwan as Dave Kim
- Stephanie Katherine Grant as Emmy Mirsky
- Jacob Hopkins as Chad Kremp
- Jennifer Irwin as Virginia Kremp
- Mindy Sterling as Linda Schwartz
- Stephanie Courtney as Essie Karp
- Sean Marquette as Johnny Atkins
- Stephen Tobolowsky as Principal Earl Ball
- Matt Bush as Andy Cogan
- Noah Munck as "Naked" Rob Smith
- Shayne Topp as Matt Bradley
- Natalie Alyn Lind as Dana Caldwell
- Sadie Stanley as Brea Bee
|Title||Written by||Directed by||Prod. code||Air Date|
|186||1||The Goldbergs' Excellent Adventure||David Guarascio||Lew Schneider||901||September 22, 2021|
|187||2||Horse Play||Mike Sikowitz||Lew Schneider||902||September 29, 2021|
|188||3||Riptide Waters||Jonathan Howard & Peter Dirksen||Jason Blount||903||October 6, 2021|
|189||4||The William Penn Years||Aaron Kaczander||Jason Blount||904||October 13, 2021|
|190||5||An Itch Like No Other||905||October 20, 2021|
|191||6||The Hunt for the Great Albino Pumpkin||906||October 27, 2021|
|192||7||The Rose-Kissy Thing||907||November 3, 2021|
- This season was confirmed on May 14, 2021.
- On July 15, 2021, it was announced that the season would premiere on September 22, 2021.
- This season retained the prior season's timeslot, Wednesdays at 8:00pm/7:00c.
- This season will likely feature Adam's high school graduation, as well as his eighteenth birthday.
- Filming for this season began on August 12, 2021.
- This is the first season without Pops after the passing of his portrayer, George Segal on March 23, 2021.
- This season premiered with a tribute to the 1989 film Bill & Ted's Excellent Adventure, as well as honoring the late George Segal and continuing the tradition of paying homage to a movie in the season opener. Per Wendi McLendon-Covey, "Every time we open a season, it's a movie tribute. We're doing one that takes us on the journey of where to spread Pops' ashes. It's hysterically funny, and you'll cry your eyes out. Sean Giambrone and I could barely get through filming."
- A.J. Michalka will return as Lainey Lewis in this season; though it's currently unknown if this will be a recurring or guest role.
- Kelli Berglund will return as Ren in this season.